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What is the main difference between a prokaryote and a eukaryote?

  1. Prokaryotes are smaller

  2. Prokaryotes are anaerobic

  3. Prokaryotes lack a nucleus

  4. Prokaryotes lack organelles

The correct answer is: Prokaryotes lack a nucleus

A This is not the main difference between prokaryotes and eukaryotes. Both can vary in size. B: This is not the main difference between prokaryotes and eukaryotes. Both can be aerobic or anaerobic. D: This is not the main difference between prokaryotes and eukaryotes. While prokaryotes may lack certain organelles, it is not the main defining feature. The main difference is that they lack a true nucleus, as mentioned in choice C.