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The Hardy-Weinberg Principle states that if the population is ___ and ___, then allele frequencies will remain constant over time.

  1. Expanding, structure-less

  2. Isolated, stable

  3. Expanding, diversifying

  4. Isolated, reproductively neutral

The correct answer is: Isolated, reproductively neutral

The Hardy-Weinberg Principle states that if the population is isolated (meaning no migration) and reproductively neutral (meaning all individuals have the same chance of mating and reproducing), then allele frequencies will remain constant over time. This means that the population is not changing and there is no new genetic variation being introduced. Options A, C, and D include either an expanding population or diversifying populations, both of which would introduce new genetic variation and disrupt the constant allele frequencies predicted by the Hardy-Weinberg Principle. Therefore, these options are incorrect. Option B includes a stable population, which on its own would not necessarily disrupt allele frequencies. However, the key factor in the Hardy-Weinberg Principle is reproductive neutrality, and since this option does not include that factor, it is also incorrect.